Pfizer and BioNTech submitted an application to the US Food and Drug Administration for emergency use authorization of an additional booster dose of their Covid-19 vaccine for adults 65 and older who have gotten a booster dose of any of the authorized or approved vaccine, the companies said Tuesday.

The submission is based on two data sets from Israel. “Both data sets showed evidence that an additional mRNA booster increases immunogenicity and lowers rates of confirmed infections and severe illness,” the companies said in a news release.

The first data set cited in the release was an analysis of records for more than 1.1 million adults 60 and older by the Israeli Ministry of Health that showed a decreased rate of infection and severe illness after a second booster.

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