Neanderthal gene variants may boost the pain sensitivity of people who carry them and may be most common in populations with prevalent Native American ancestry, a new study finds.

The research, published Tuesday (Oct. 10) in the journal Communications Biology, focused on three versions of the SCN9A gene, which codes for a protein that shuttles sodium into cells and helps pain-detecting nerves send signals. People with any of the three variants are more sensitive to pain caused by being prodded with a sharp object, but not pain caused by heat or pressure.

“In 2020, another group of researchers studied people of European ancestry and linked these Neanderthal gene variants to increased pain sensitivity,” first study author Pierre Faux, a geneticist at the French National institute for Agriculture, Food and Environment, told Live Science.

“We extend these findings by studying Latin Americans and showing that these Neanderthal genetic variants are much more common in people with Native American ancestry,” Faux said. “We also show the type of pain these variants affect, which wasn’t known before.”

source livescience.com