Microsoft Co-Founder Paul Allen died from complications of non-Hodgkin’s lymphoma on Monday afternoon.

Allen’s Vulcan Inc. announced that he died in Seattle at 65 years old.

It is with deep sadness that we announce the death of @PaulGAllen, our founder and noted technologist, philanthropist, community builder, conservationist, musician and supporter of the arts. All of us who worked with Paul feel an inexpressible loss today. https://t.co/OMLZ7ivvSD pic.twitter.com/Bfa8kK6Q8e

— Vulcan Inc. (@VulcanInc) October 15, 2018

Allen’s sister, Jody, said he was “a remarkable individual on every level.”

“While most knew Paul Allen as a technologist and philanthropist, for us he was a much-loved brother and uncle, and an exceptional friend. Paul’s family and friends were blessed to experience his wit, warmth, his generosity and deep concern,” she said in a statement. “For all the demands on his schedule, there was always time for family and friends. At this time of loss and grief for us – and so many others – we are profoundly grateful for the care and concern he demonstrated every day.”

Allen ranked among the world’s wealthiest individuals. As of Monday afternoon, he ranked 44th on Forbes’ 2018 list of billionaires with an estimated net worth of more than $20 billion.

Through Vulcan, Allen’s network of philanthropic efforts and organizations, the Microsoft co-founder supported research in artificial intelligence and new frontier technologies. The group also invested in Seattle’s cultural institutions and the revitalization of parts of the city.

Allen owned two professional sports teams, the NFL Seattle Seahawks and NBA Portland Trailblazers. He was also an electric guitarist who occasionally jammed with celebrity musicians including Bono and Mick Jagger, and a huge music fan. He funded and designed the Experience Music Project in Seattle, devoted to the history of rock music and dedicated to his musical hero Jimi Hendrix. (It has since been re-christened the Museum of Pop Culture.) The building was designed by architect Frank Gehry to resemble a melted electric guitar.

Vulcan CEO Bill Hilf said, “All of us who had the honor of working with Paul feel inexpressible loss today.”

“He possessed a remarkable intellect and a passion to solve some of the world’s most difficult problems, with the conviction that creative thinking and new approaches could make profound and lasting impact,” Hilf said in a statement.

Earlier this month, Allen revealed that he had started treatment for non-Hodgkin’s lymphoma, the same type of cancer he was treated for in 2009. In 1983, Allen left the company he founded with Bill Gates when he was first diagnosed with Hodgkin’s disease, which he defeated.

Bill Gates, who co-founded Microsoft with Allen, said that “personal computing would not have existed without him”:

“I am heartbroken by the passing of one of my oldest and dearest friends, Paul Allen. From our early days together at Lakeside School, through our partnership in the creation of Microsoft, to some of our joint philanthropic projects over the years, Paul was a true partner and dear friend. Personal computing would not have existed without him.

But Paul wasn’t content with starting one company. He channeled his intellect and compassion into a second act focused on improving people’s lives and strengthening communities in Seattle and around the world. He was fond of saying, “If it has the potential to do good, then we should do it.” That’s the kind of person he was.

Paul loved life and those around him, and we all cherished him in return. He deserved much more time, but his contributions to the world of technology and philanthropy will live on for generations to come. I will miss him tremendously.”

Current Microsoft CEO Satya Nadella said Allen made “indispensable” contributions to Microsoft and the technology industry. Nadella also said he learned a lot from Allen and will continue to be inspired by him.

“As co-founder of Microsoft, in his own quiet and persistent way, he created magical products, experiences and institutions, and in doing so, he changed the world,” Nadella said in a statement.

Former Microsoft CEO Steve Ballmer called Allen a “truly wonderful, bright and inspiring person.”

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